the Court of Hearts

Aging Skin presents leading-edge strategies to treat problems of aging skin. Current concepts are presented, along with fundamental research detailing the biochemical mechanisms underlying photodamage—the hallmark of aging skin. Based on the premise that aging and senescence occur due to a deterioration of cutaneous repair systems, topics covered include:

Novel approaches using growth factors that regulate fi brosis to facilitate “cutaneous wound repair” while preventing “solar scar”
Role of matrix metalloproteinases in the repair of photodamage
Role of angiogenesis and lymphangiogenesis in response to photodamage and strategies to regulate these processes
DNA repair and oxidative stress-resistant systems that aid in combating aging skin
Hormonal infl uences on skin aging, benefi t of hormone replacement therapy and role of nutrition
Nonenzymatic glycation of matrix proteins due to oxidative stress-altering functionality and strategies to block such untoward reactions
Success of current treatments—retinoic acid, dermabrasion, Botox, peels and fi llers
Design of the “optimal sunscreen” for prevention of photodamage
New skin-whitening strategies to reduce age spots by influencing melanogenesis

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Author Expertise
Linda D. Rhein, PhD, has more than 25 years experience in dermatology